miR-497 regulates neuronal death in mouse brain after transient focal cerebral ischemia
نویسندگان
چکیده
منابع مشابه
ultrastructural study of neuronal death in rat hippocampus after transient and permanent focal cerebral ischemia
objective: morphological changes of ca1 neurons in rat hippocampus after transient and permanent focal cerebral ischemia were studied to clarify the nature of postischemic cell death in the subfield. materials and methods: male adult rats were divided into 3 groups: control (shamoperated), transient ischemic group (30 minutes of mcao followed by 48 hours of reperfusion), and permanent ischemic ...
متن کاملL-NAME and 7-Nitroindazole Reduces Brain Injuries in Transient Focal Cerebral Ischemia in Rat
Background: The role of nitric oxide (NO) of endothelial or neuronal origins in cerebral ischemia and reperfusion injuries are far from being settled, extending from being important to not having any role at all. Objective: To investigate the role of NO of endothelial and neuronal origins in ischemia/reperfusion injuries in focal cerebral ischemia, L-NAME, a non selective NO synthase inhibitor...
متن کاملQuantitative evaluation of Blood Brain Barrier permeability in transient focal cerebral ischemia in the rat
Introduction: Development of brain edema following focal cerebral ischemia exacerbates primary ischemic injury. Blood brain barrier (BBB) opening is an important part of edema named as vasogenic brain edema. In this study, quantitative alterations of BBB permeability is experimentally evaluated using transient focal cerebral ischemia in the rat. Methods: Two groups of male rats (ischemic and sh...
متن کاملDiabetes activates cell death pathway after transient focal cerebral ischemia.
It is well known that diabetes aggravates brain damage in experimental and clinical stroke subjects. Diabetes accelerates maturation of neuronal damage, increases infarct volume, and induces postischemic seizures. The mechanism by which diabetes increases ischemic brain damage is still elusive. Our previous experiments indicate that mitochondria dysfunction may play a role in neuronal death. Th...
متن کاملEffect of pentoxifylline on brain edema in a rat model of transient focal cerebral ischemia
Pervious studies have shown that pentoxifylline (PTX) has beneficial effects in reduction of stroke and brain trauma injuries in experimental animals. However, there is very little and controversial information about the effect of PTX on brain edema in cerebral ischemia. Therefore, the aim of this study was to determine the effects of different doses of PTX on brain edema and neurological m...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neurobiology of Disease
سال: 2010
ISSN: 0969-9961
DOI: 10.1016/j.nbd.2009.12.021